Glossary entry (derived from question below)
German term or phrase:
Wirkfluktuation
English translation:
motor fluctuations (connected with gaps in medication effectiveness)
Added to glossary by
Stuart and Aida Nelson
Jun 1, 2019 05:48
5 yrs ago
7 viewers *
German term
Wirkfluktuation
German to English
Medical
Medical (general)
M. Parkinson vom akinetisch-rigiden Typ rechtsbetont mit ***Wirkfluktuation*** und Hyperkinesen
What is the appropriate term in English? Any suggestions?
What is the appropriate term in English? Any suggestions?
Proposed translations
(English)
Change log
Jun 15, 2019 11:33: Stuart and Aida Nelson Created KOG entry
Proposed translations
+2
6 hrs
Selected
motor fluctuations (connected with gaps in medication effectiveness)
I don't know if there is a standard term in English for Wirkfluktuation. I couldn't find any references to fluctuations of medication effectiveness but quite a lot about motor fluctuations.
Medication often loses its effectiveness with progression of the disease which causes motor fluctuations.
At this point, motor fluctuations (also called “on-off” fluctuations) may begin to appear.
They are designed to take effect quickly: within 15 minutes or less. Typically, the response is short, maybe an hour or two. It is called “rescue” therapy because it bridges gaps in other medication effectiveness.
Although at this time there is no way to correct the brain changes that cause Parkinson’s, we know that exercise can help you maintain your ability chapter one About Parkinson’s Disease 5 to fight the disease and that staying healthy can reduce setbacks that make PD progress faster.
https://parkinson.org/sites/default/files/attachments/MidStr...
Fluctuations in performance in patients with Parkinson's disease on chronic levodopa therapy (the "on-off" effect) are due to several factors. The increasing severity during treatment of early morning akinesia, "freezing" episodes, and end-of-dose deterioration are probably due to progression of the underlying disease. Peak-dose dyskinesia and peak-dose akinesia are due to levodopa over-dosage. "Yo-yo-ing", which is the severest form of such fluctuation in mobility and dyskinesias, may represent the sum of these disorders.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
Die Behandlung mit Medikamenten ist bei Parkinson-Patienten ein wesentlicher Bestandteil der Therapie. Individuell auf den Patienten und seine Beschwerden abgestimmt, können Parkinson-Medikamente die Krankheitssymptome lange Zeit deutlich verbessern. Mit zunehmender Krankheitsdauer kann jedoch die Wirksamkeit der Medikamente nachlassen, und es können sogenannte Spätkomplikationen auftreten. Dies gilt vor allem für Arzneimittel, die den fehlenden Botenstoff Dopamin im Gehirn ersetzen sollen (L-Dopa, dopaminerge Medikamente).
https://www.parkinson-aktuell.de/was-ist-parkinson/parkinson...
Befragt zur Medikation gab ein Drittel an, fünf oder mehr Medikamente täglich zu benötigen, 30 Prozent mussten fünfmal täglich ein Medikament einnehmen, so Wüllner auf dem Parkinsonkongress in Ulm. Auf die Frage, was bei der Therapie verbessert werden sollte, gaben 53 Prozent an, dass sie sich eine Therapie wünschen, die Wirkungsfluktuationen stärker lindert, also plötzlich auftretende Phasen schlechter Beweglichkeit reduziert
https://www.aerztezeitung.de/medizin/krankheiten/neuro-psych...
4 KudoZ points awarded for this answer.
Comment: "Selected automatically based on peer agreement."
2 hrs
fluctuating presence/activity
Perhaps
6 hrs
fluctuations of the (therapeutic) effect/ changes in effectiveness
fluctuations of the (therapeutic) effect
changes in effectiveness
effective fluctuation
5 days
fluctuation
Fluctuation alone in this context. The rest of the text gives away the meaning.
Reference:
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