English to Russian Medical Medical: Pharmaceuticals

The time slope of each key secondary endpoint will be analyzed using a linear mixed effects model with each parameter (ie, KCCQ-OS, or GLS%, or 6MWT, or SF-36 v2 PCS) as dependent variable and treatment, baseline value for each parameter, time (as a continuous variable), geographic region, and treatment by time interaction as fixed effect and intercept and time as random effects. The parameter of interest is the coefficient for study intervention group and time interaction term, which measures the slope difference between CAEL-101 and placebo over time.