Dec 6, 2005 11:31
18 yrs ago
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English term
United Kingdom
Communicate. Collaborate. Connect
Native in: English (Variant: British)
Works in: Spanish to English, English
all but Ca2+
English
Science
Biology (-tech,-chem,micro-)
progesterone receptors
In summary, in addition to GnRH self-priming induced by cross-talk of the cAMP-PKA pathway with PR, the originality of our results lies in the discovery that the LH secretory response to GnRH involves a Ca2+-independent PKC interaction with PR. Thus, all but Ca2+, intracellular signalling of GnRH might phosphorylate a promiscuous PR (Denner et al, 1990) in a ligand-independent manner, improving the effect of the hypothalamic decapeptide on LH release.
What do they mean here?
thanks
What do they mean here?
thanks
Responses
+2
1 hr
Helen Genevier
France
France
Native in English
&
English
Specializes in field
France
Related KudoZ points
:
16
Selected
apart from Ca2+ mobilisation + alter the sentence a bit
Thus, the intracellular pathways activated by GnRH, apart from Ca2+ mobilisation, may phosphorylate a promiscuous PR (Denner et al, 1990) in a ligand-independent manner, potentiating the effect of the hypothalamic decapeptide on LH release.
4 KudoZ points awarded for this answer.
Comment: "lovely stuff
cheers"
4 mins
Elena Petelos
United Kingdom
United Kingdom
Specializes in field
United Kingdom
Medical, Legal, Technical
Native in: Greek
Works in: English to Greek, Greek to English, French to English, and 3 more.
Related KudoZ points
:
4
(the release/presence) of calcium ion is not required (for interaction with PR)
Released calcium ions can activate PKC, but in your case the presence of (release of) calcium ions is not necessary for the interaction with PR.
Diacylglycerol binds to and activates protein kinase C (PKC). The IP3 binds to ligand-gated receptor/Ca++ channels on internal membranes, leading to an influx of calcium ions into the cytoplasm. Calcium ions bind to a calcium modulatory protein, calmodulin, which binds to and activates the calmodulin-dependent kinase (CAM-PK). ------------The released calcium ions also activate PKC.----- As in the previous example, these receptors which interact with G proteins are single polypeptide chains which contain 7 membrane spanning alpha helices. The cycle of degradation and resynthesis of PIP2 is called the PI cycle.
Diacylglycerol binds to and activates protein kinase C (PKC). The IP3 binds to ligand-gated receptor/Ca++ channels on internal membranes, leading to an influx of calcium ions into the cytoplasm. Calcium ions bind to a calcium modulatory protein, calmodulin, which binds to and activates the calmodulin-dependent kinase (CAM-PK). ------------The released calcium ions also activate PKC.----- As in the previous example, these receptors which interact with G proteins are single polypeptide chains which contain 7 membrane spanning alpha helices. The cycle of degradation and resynthesis of PIP2 is called the PI cycle.
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