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23:34 Apr 21, 2021 |
English to Spanish translations [PRO] Medical - Medical: Pharmaceuticals / SV40 large tumor antigen‐catalyzed unwinding | |||||||
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| Selected response from: Marcelo Viera Uruguay Local time: 10:07 | ||||||
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sv40 large tumor antigen‐catalyzed unwinding desenrrollado catalizado por el antígeno tumoral grande SV40 Explanation: La replicación del ADN requiere de una enzima llamada helicasa que desenrolla la doble hélice. Otras enzimas sintetizan el nuevo ADN copiando la secuencia de las cadenas de la doble hélice original. Una de las cadenas se copia de forma continua, mientras que la otra cadena se copia en secciones. https://www.biointeractive.org/es/classroom-resources/replic... SV40 es un poliomavirus capaz de inducir tumores tanto en monos como en otros animales de experimentación. Dispone de una proteína codificada por su genoma, el mencionado antígeno T, capaz de unirse y bloquear al antioncogen celular p53, guardián del buen desarrollo del ciclo celular The simian virus 40 (SV40) large T antigen (large tumor antigen), in conjunction with a topoisomerase, a DNA binding protein, and ATP, catalyzed the conversion of a circular duplex DNA molecule containing the SV40 origin of replication to a form with unusual electrophoretic mobility that we have named form U. https://pubmed.ncbi.nlm.nih.gov/3025851/ -------------------------------------------------- Note added at 4 hrs (2021-04-22 03:42:44 GMT) -------------------------------------------------- A new target in cancer therapy is DNA unwinding enzymes known as helicases. Helicases play critical roles in all aspects of nucleic acid metabolism. https://www.frontiersin.org/articles/10.3389/fmolb.2018.0005... https://pubmed.ncbi.nlm.nih.gov/3025851/ |
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11 hrs confidence:
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